International peer-reviewed journal Oncotarget was recently cited for publishing research concerning breakthroughs in resistance to treatment for esophageal cancer. Many people with this type of cancer have shown a resistance to radiotherapy, and scientists at Trinity College Dublin, led by Dr Stephen Maher, have discovered for the first time that a missing molecule in cancer stem cells, miR17, is a significant cause of resistance to radiotherapy.
It was published in Oncotarget that the research team, including specialists from St James’s Hospital Dublin, the University of Hull in the UK and the Coombe Women and Infant’s University Hospital, showed that tumors that had more cancer stem cells were larger and more aggressive than others, and that these cancer stem cells were less responsive to radiotherapy. This helps scientists understand why certain tumors are resistant to treatment, and will further help them develop treatments which target cancer stem cells in esophageal cancer patients for a higher cure rate. Oncotarget is also available on Dove Press.
This type of cancer, esophageal adenocarcinoma, attacks the food-pipe, and is growing more common in developed countries. Diagnosis has increased by 600% in the last thirty years. This is the highest rate of growth of any disease in the same time frame and experts predict that this will continue to rise over next two decades.
Oncotarget is an online free-access traditional medical journal crossing multiple disciplines, and is published weekly. It’s goal is to make the results of scientific studies available quickly, with notable scientists all over the globe reviewing and sharing the most recent research within the full range of, as well as across, medical specialties and sub-specialties. Follow Oncotarget journal on Twitter.
The highest aim of the publishers and contributors to Oncotarget is “Life without disease.” And because of their success, they are publishing studies aside from oncology, and are now reporting breakthroughs in other medical fields such as aging, pathology, immunology, microbiology, neurotarget, neuroscience, autophagy, cell death, and circadian rhythm. Learn more about Oncotartget at http://www.oncotarget.com.